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Who we are

We are dedicated to researching kidney diseases. Our team has a great enthusiasm to find out how kidney diseases develop. Our team is willing to challenge new technology to keep ourselves updated. We are well experienced in handling animal kidney disease models. To achieve precision medicine, our team is working on translational research with our own large biobank for human kidney tissue. We believe multi-omics analyses such as genomics, transcriptomics, epigenomics, metabolomics, and proteomics help to understand the underlying mechanism of kidney diseases. 

Our Team



Molecular mechanism

of  kidney disease 

single cell, omics

Omics analysis

at single-cell level  

mitochondria, metabolism

Metabolic changes in kidney disease

gwas, genome

Genetic association with kidney disease

kidney tubule, immune cell

Contribution of altered tubules to kidney fibrosis

open lab

More and more 

about kidney

We are open to Graduate students, International Students, Postdocs,
and Research assistants! 

Please contact us!

Link of Interests
Always NU
Master and Doctoral Course
Nagoya University Graduate School of Medicine


NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury.

Doke T, Mukherjee S, Mukhi D, Dhillon P, Abedini A, Davis JG, Chellappa K, Chen B, Baur JA, Susztak K. 

Nat Metab. 2023 

Single-cell analysis highlights differences in druggable pathways underlying adaptive or fibrotic kidney regeneration.

Balzer MS, Doke T, Yang YW, Aldridge DL, Hu H, Mai H, Mukhi D, Ma Z, Shrestha R, Palmer MB, Hunter CA, Susztak K. 

Nat Commun. 2022

Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease.

Liu H, Doke T, Guo D, Sheng X, Ma Z, Park J, Vy HMT, Nadkarni GN, Abedini A, Miao Z, Palmer M, Voight BF, Li H, Brown CD, Ritchie MD, Shu Y, Susztak K.

Nat Genet. 2022

Single-cell analysis identifies the interaction of altered renal tubules with basophils orchestrating kidney fibrosis.

Doke T, Abedini A, Aldridge DL, Yang YW, Park J, Hernandez CM, Balzer MS, Shrestra R, Coppock G, Rico JMI, Han SY, Kim J, Xin S, Piliponsky AM, Angelozzi M, Lefebvre V, Siracusa MC, Hunter CA, Susztak K.

Nat Immunol. 2022 

Genome-wide association studies identify the role of caspase-9 in kidney disease.

Doke T, Huang S, Qiu C, Sheng X, Seasock M, Liu H, Ma Z, Palmer M, Susztak K.

Sci Adv. 2021

Transcriptome-wide association analysis identifies DACH1 as a kidney disease risk gene that contributes to fibrosis.

Doke T, Huang S, Qiu C, Liu H, Guan Y, Hu H, Ma Z, Wu J, Miao Z, Sheng X, Zhou J, Cao A, Li J, Kaufman L, Hung A, Brown CD, Pestell R, Susztak K.

J Clin Invest. 2021

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